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Miconazole or Clotrimazole: what is better and what is the difference

Under favorable conditions, the fungi quickly infect human tissues; a bacterial infection can also connect to the disease. To eliminate them, drugs with imidazole derivatives are more often used. Which is better: Miconazole or Clotrimazole – the doctor will prompt after receiving the results of the tests.

After all, the substances of means, though they belong to the same group, but the range of their actions differs.

The main characteristic of antimycotics

Miconazole, Clotrimazole belong to a wide spectrum antifungal agents. The active substances of drugs are included in the group of synthetic compounds of imidazole and are used in the treatment of those diseases whose pathogens are sensitive to their action.

Effective Miconazole and Clotrimazole against fungi and bacteria of the form:

  • Candida (albicans and other species);
  • Malassezia furfur;
  • Trichophyton (rubrum, mentagrophytes);
  • Epidermophyton floccosum;
  • Corynebacterium minutissimum;
  • Staphylococcus;
  • Streptococcus.

Drugs cause the death of the pathogen, disrupting the synthesis of cell membrane components. Their substances in high concentrations suppress the vital activity of gram-positive microbes.

The difference between miconazole and clotrimazole:


Active substance

Action of the active substance

Has antifungal, antibacterial property.

In addition to the antimycotic and antibacterial action, it also has a trichomonacid, antiprotozoal effect.

Other substance sensitive pathogens

Cream for external use Miconazole (Darnitsa, Sandoz, Hexal)

Clotrimazole for intravaginal administration: cream 2%, tablets 100 mg, suppositories 100 mg

Cheekable tablets Miconazole Nitrate

Clotrimazole for external use: cream 1%, gel 1%, ointment 1%, solution 1%

Remedies with miconazole and topical or clotrimazole can cause itching, burning, rash, tingling, hyperemia, nausea. In case of severe irritation or allergic reaction, the use of the drug is discontinued.

Indications antimycotics

Means are also prescribed for:

  • multi-colored lichen;
  • onychomycosis;
  • trichophytosis;
  • seborrheic dermatitis;
  • folliculitis;
  • mycosis of skin, hair, beard;
  • erythrasma;
  • pseudomycosis;
  • other mycotic diseases, including favus (scab), microsporia;
  • pathologies caused by gram-positive bacteria;
  • mixed infections.

Miconazole and Clotrimazole are also prescribed for the prevention and treatment of fungal-bacterial infection in the setting of inflammatory urogenital diseases. Cheek tablets work well with oropharyngeal candidal stomatitis.

Clotrimazole is used to treat urogenital trichomoniasis, gardnerellosis and infections caused by gram-negative bacteria. Miconazole is ineffective against these diseases.

Contraindications antimycotics

Miconazole cream is forbidden to use in case of intolerance to miconazole and patients under 12 years. Cheek tablets are contraindicated in preschool children.

All forms of clotrimazole may not be used by people who are hypersensitive to clotrimazole. Means for intravaginal administration are contraindicated in children and girls before sexual activity.

It is forbidden to apply Clotrimazole simultaneously with Miconazole. . Their substances belong to the same imidazole group, so there is a high probability of overdose, with subsequent aggravation of the side effects of clotrimazole, miconazole.

Doctor’s recommendations

During the period of treatment with miconazole or clotrimazole, lactating women are advised to feed the child with artificial mixtures. Means of local action is not used in the first trimester, and systemic drugs – throughout pregnancy.

Vaginal suppositories / tablets are shown to sexually active patients.

In case of fungal blepharitis, it is impossible to use linings with miconazole or clotrimazole to treat areas of eyelash growth. If the cream, ointment, solution, gel preparations for external and / or local use got on the mucous membrane of the eyes, it is abundantly washed with saline or water.

Gynecologists prefer Clotrimazole because it copes better with mixed and urogenital infections, and also costs less. Podologists note the good efficacy of Miconazole cream against nail fungus.

Lintimenti with clotrimazole have no age restrictions, so they are recommended to use pediatric dermatologists. Clotrimazole solution is more suitable for oropharyngeal thrush in infants.

Synonyms of antimycotics

Synonyms of drugs are drugs containing the same active ingredients. Analogen to Clotrimazole include Amiklon, Yenamazole 100, Guine-Lotrimin, Candide and other products with clotrimazole.

Synonymous with Miconazole are vaginal suppositories Gyno-Dactanol, Ginesol 7, Myco-Penotran. The direct analogues of the cream include Daktarin, Mikogel.

Ketoconazole, isoconazole has the same antifungal properties with clotrimazole and miconazole. With ketoconazole, Dermazole, Nizoral, Perhohotal are released, and with isoconazole, Travogen cream and candles are released.

If a person is intolerant of the above substances, the doctor may recommend products with dequalinium chloride, fluconazole, sertaconazole, fenticonazole.

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